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KMID : 1130320150580090325
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Korean Journal of Pediatrics
2015 Volume.58 No. 9 p.325 ~ p.329
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Vitamin D serum levels in children with allergic and vasomotor rhinitis
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Lee Seung-Jin
Kang Bong-Hwa
Choi Bong-Seok
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Abstract
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Purpose: In addition to regulating calcium and phosphorus homeostasis and bone metabolism, vitamin D is known as an immune modulator. Recently, there has been increased worldwide interest in the association between low levels of vitamin D and allergic diseases. The purpose of this study was to assess the relationship between serum vitamin D levels and allergic/vasomotor rhinitis (AR/VR) in children.
Methods: This study included 164 patients. The sample included 59 patients with AR, 42 patients with VR, and 63 controls. Their ages ranged from 0 to 16 years. We examined the levels of 25-hydroxyvitamin D, Immunoglobulin E, specific IgE, and eosinophil cationic protein; peripheral blood eosinophil count; and the results of a skin prick test.
Results: Serum 25-hydroxyvitamin D levels were 19.0±8.5 ng/mL in the AR group, 25.5±10.9 ng/ mL in the VR group, and 26.9±10.7 ng/mL in the control group. After adjustment for body mass index and season at the time of blood sampling, vitamin D levels in the AR group were lower than those of the VR group (P=0.003) and control group (P<0.001). Vitamin D levels were inversely correlated with Immunoglobulin E levels (r=?0.317, P<0.001). AR patients with food allergy or atopic dermatitis did not have lower levels of 25-hydroxyvitamin D than AR patients without these diseases.
Conclusion: This study demonstrates a possible relationship between vitamin D levels and allergic rhinitis in Korean children.
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KEYWORD
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Allergic rhinitis , Vitamin D , Child, Vasomotor rhinitis , Immunoglobulin E
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